Zu "K05743" wurden 56 Artikel gefunden!
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Anti-Recombinant LIMK1, clone A762
Artikelnummer: E-AN302042L.100
LIM kinases (LIMK1 and LIMK2) are serine/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their amino-terminal regulatory domains. LIM kinases are involved in actin cytoskeletal regulation downstream of Rho-family GTPases, PAKs, and ROCK. PAK1 and ROCK phosphorylate LIMK1 or LIMK2 at the...
| Schlagworte: | Anti-LIMK1, Anti-LIM domain kinase 1, Recombinant LIMK1 Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
SR 7826
Artikelnummer: Cay32976-10
SR 7826 is an inhibitor of LIM kinase 1 (LIMK1, IC50 = 43 nM). It is selective for LIMK1 over Rho-associated kinase 1 (ROCK1) and ROCK2 (IC50s = 6,565 and 5,536 nM, respectively) and a panel of 60 kinases at 1 µM but does inhibit serine/threonine kinase 16 (STK16) by greater than 80% at 1 µM. SR 7826 inhibits the...
| Schlagworte: | N-(2-hydroxyethyl)-N'-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-N-phenyl-urea |
| Anwendung: | LIMK1 inhibitor |
| CAS | 1219728-20-7 |
| MW: | 387.43 D |
ab 221,00 €
MDI-114215
Artikelnummer: Cay42919-1
MDI-114215 is an allosteric inhibitor of LIM kinase 1 (LIMK1) and LIMK2 (IC50s = 19. and 26. nM, respectively). It is selective for LIMK1 and LIMK2 in a panel of 468 kinases but does bind to cyclin-dependent kinase 7 (Cdk7), MAP kinase kinase 7 (MKK7), vaccinia-related kinase 2 (VRK2), and phosphorylated Abl1 at 300...
| Schlagworte: | N-(cyclopropylmethyl)-N-(4-((2-hydroxyethyl)amino)benzyl)-4-(N-phenylsulfamoyl)benzamide |
| Anwendung: | Allosteric LIMK1 / LIMK2 inhibitor |
| MW: | 479.6 D |
ab 112,00 €
BMS-5
Artikelnummer: SYN-1024-M005
Soluble in DMSO. Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has...
| Schlagworte: | BMS5 |
| Anwendung: | LIMK1 / LIMK2 inhibitor |
| CAS | 1338247-35-0 |
| MW: | 431,3 D |
ab 123,00 €
Anti-LIMK1
Artikelnummer: A302-670A
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue...
| Schlagworte: | Anti-LIMK, Anti-LIMK1, Anti-LIMK-1, EC=2.7.11.1, Anti-LIM domain kinase 1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-LIMK1
Artikelnummer: A302-671A
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue...
| Schlagworte: | Anti-LIMK, Anti-LIMK1, Anti-LIMK-1, EC=2.7.11.1, Anti-LIM domain kinase 1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-LIM Kinase
Artikelnummer: 600-401-855
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue...
| Schlagworte: | Anti-LIMK, Anti-LIMK1, Anti-LIMK-1, EC=2.7.11.1, Anti-LIM domain kinase 1 |
| Anwendung: | ELISA, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
733,00 €
Anti-LIM Kinase 1 / LIMK1
Artikelnummer: NSJ-R32135
0.5mg/ml if reconstituted with 0.2ml sterile DI water. LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc...
| Schlagworte: | Anti-LIMK, Anti-LIMK1, Anti-LIMK-1, EC=2.7.11.1, Anti-LIM domain kinase 1, LIM Kinase 1 Antibody / LIMK1 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
BMS-3
Artikelnummer: AG-CR1-2901-M025
Off-white solid. Soluble in DMSO (5mg/ml). Potent LIMK (Lim kinase) inhibitor. Has IC50 values of 5nM and 6nM for LIMK1 and LIMK2, respectively.
| Schlagworte: | N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2- yl)cyclopropanecarboxamide |
| Anwendung: | Potent LIMK inhibitor |
| CAS | 1338247-30-5 |
| MW: | 429,3 D |
ab 88,00 €
BMS-3
Artikelnummer: Cay19421-10
BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively). It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.Formal Name:...
| Schlagworte: | N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide |
| Anwendung: | LIMK1 / LIMK2 inhibitor |
| CAS | 1338247-30-5 |
| MW: | 429.3 D |
ab 49,00 €
Anti-LIMK1
Artikelnummer: E-AB-13381.120
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM...
| Schlagworte: | Anti-LIMK, Anti-LIMK1, Anti-LIMK-1, EC=2.7.11.1, Anti-LIM domain kinase 1, LIMK1 Polyclonal Antibody |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
BMS-5
Artikelnummer: Cay21072-10
BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively. LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin. This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho...
| Schlagworte: | LIM Kinase Inhibitor I, LIMKi 3,... |
| Anwendung: | LIMK1 / LIMK2 inhibitor |
| CAS | 1338247-35-0 |
| MW: | 431.3 D |
ab 72,00 €