Protein function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. [The UniProt Consortium]
Human (Erwartet: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A301-959A-T maps to a region between residue 1350 and 1400 of human leukemia-associated rho guanine nucleotide exchange factor using the numbering given in entry NP_056128.1 (GeneID 23365).