Anti-ITK

Anti-ITK
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R35674-100UG 100 µg - -

3 - 10 Werktage*

755,00 €
 
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s)... mehr
Produktinformationen "Anti-ITK"
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: IL2-inducible T-cell kinase Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. [The UniProt Consortium]
Schlagworte: Anti-EMT, Anti-ITK, Anti-Kinase EMT, EC=2.7.10.2, Anti-T-cell-specific kinase, Anti-Tyrosine-protein kinase Lyk, Anti-IL-2-inducible T-cell kinase, Anti-Tyrosine-protein kinase ITK/TSK, Anti-Interleukin-2-inducible T-cell kinase, ITK Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: R35674

Eigenschaften

Anwendung: WB, ELISA (peptide)
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Goat
Spezies-Reaktivität: human
Immunogen: Amino acids RLLRQLAEIAESGL were used as the immunogen for this ITK antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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