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ITK, His & GST & Strep-II, Mouse
Artikelnummer: GSC-Z06229-100
ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well as Th2, Th9 and Th17 responses thereby controlling the expression of pro-inflammatory cytokines.
| Schlagworte: | Itk, Kinase TLK, Kinase EMT, T-cell-specific kinase, IL-2-inducible T-cell kinase, Tyrosine-protein kinase ITK/TSK |
| Ursprungsart: | mouse |
| MW: | 61.42 kD |
ab 497,00 €
PF-06465469
Artikelnummer: Cay31118-10
PF-06465469 is a covalent inhibitor of IL-2-inducible T cell kinase (Itk, IC50 = 2 nM). It also inhibits Bruton's tyrosine kinase (BTK, IC50 = 2 nM). PF-06465469 inhibits Itk phosphorylation of phospholipase Cgamma (PLCgamma) induced by an anti-CD3 antibody in Jurkat cells (IC50 = 57 nM). It induces apoptosis in...
| Schlagworte: | 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)... |
| Anwendung: | Itk covalent inhibitor |
| CAS | 1407966-77-1 |
| MW: | 523.63 D |
ab 147,00 €
BMS 509744
Artikelnummer: Cay34148-1
An Itk inhibitor (IC50 = 19 nM), selective for Itk over 18 other kinases (IC50s = >1,100 nM for all), inhibits IL-2 secretion from Jurkat T cells and isolated human PBMCs induced by antibodies targeting CD3 (IC50s = 0.25 and 0.39 µM, respectively), decreases serum levels of Il-2 and the lung infiltration of total...
| Schlagworte: | N-[5-[[5-[(4-acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]m... |
| Anwendung: | Itk inhibitor |
| CAS | 439575-02-7 |
| MW: | 623.83 D |
ab 52,00 €
ITK, active human recombinant protein
Artikelnummer: BPS-40445
Active recombinant human ITK (352-end) was expressed in Sf9 cells using an N-terminal GST tag. The gene accession number is NM_005546.
| Schlagworte: | EMT, ITK, Kinase EMT, EC=2.7.10.2, T-cell-specific kinase, Tyrosine-protein kinase Lyk, IL-2-inducible T-cell kinase,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 57 kD |
536,00 €
ITK Kinase Assay Kit
Artikelnummer: BPS-78429
The ITK Kinase Assay Kit is designed to measure ITK kinase activity for screening and profiling applications using ADP-Glo(R) as a detection reagent.
| Schlagworte: | EMT, ITK, Kinase EMT, EC=2.7.10.2, T-cell-specific kinase, Tyrosine-protein kinase Lyk, IL-2-inducible T-cell kinase,... |
| Anwendung: | Enzyme kinetics, small molecular inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
Anti-ITK, C-terminal
Artikelnummer: ARG63136.100
Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation...
| Schlagworte: | Anti-ITK, Anti-EMT, Anti-Kinase EMT, EC=2.7.10.2, Anti-T-cell-specific kinase, Anti-Tyrosine-protein kinase Lyk,... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
ITK(Lyk), active murine recombinant, N-terminal GST-tag
Artikelnummer: BPS-40446
Active murine recombinant IL2-inducible T-cell kinase (ITK), also known as Lyk and TSK (GenBank Accession #NM_010583),a.a. 352-620(end) with N-terminal GST-tag, MW= 57 kDa, expressed in Sf9 cells via abaculovirus expression system.
| Schlagworte: | Emt, Itk, Kinase EMT, Kinase TLK, EC=2.7.10.2, T-cell-specific kinase, IL-2-inducible T-cell kinase, Tyrosine-protein... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| MW: | 57 kD |
536,00 €
ITK(Lyk), active rat recombinant, N-terminal GST-tag
Artikelnummer: BPS-40447
Active rat recombinant IL2-inducible T-cell kinase (ITK), also known as Lyk and TSK (GenBank Accession #NM_010583),a.a. 352-620(end) with N-terminal GST-tag, MW= 57 kDa, expressed in Sf9 cells via abaculovirus expression system.
| Schlagworte: | Tyrosine-protein kinase, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| MW: | 57 kD |
536,00 €
Anti-ITK
Artikelnummer: NSJ-R34415-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: IL2-inducible T-cell kinase Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation...
| Schlagworte: | Anti-EMT, Anti-ITK, Anti-Kinase EMT, EC=2.7.10.2, Anti-T-cell-specific kinase, Anti-Tyrosine-protein kinase Lyk,... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, rat |
836,00 €
Anti-ITK
Artikelnummer: NSJ-R35674-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: IL2-inducible T-cell kinase Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation...
| Schlagworte: | Anti-EMT, Anti-ITK, Anti-Kinase EMT, EC=2.7.10.2, Anti-T-cell-specific kinase, Anti-Tyrosine-protein kinase Lyk,... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
Anti-ITK
Artikelnummer: E-AB-15142.120
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. Protein function: Tyrosine kinase that plays an essential role in regulation...
| Schlagworte: | Anti-ITK, Anti-EMT, Anti-Kinase EMT, EC=2.7.10.2, Anti-T-cell-specific kinase, Anti-Tyrosine-protein kinase Lyk,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
Anti-ITK
Artikelnummer: ARG11026.50
Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation...
| Schlagworte: | Anti-EMT, Anti-ITK, Anti-Kinase EMT, EC=2.7.10.2, Anti-T-cell-specific kinase, Anti-Tyrosine-protein kinase Lyk,... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
575,00 €