Anti-IRF3

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG56578.50 50 µg - -

6 - 14 Werktage*

520,00 €
 
Protein function: Key transcriptional regulator of type I interferon (IFN)-dependent immune... mehr
Produktinformationen "Anti-IRF3"
Protein function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. [The UniProt Consortium]
Schlagworte: Anti-IRF3, Anti-IRF-3, Anti-Interferon regulatory factor 3
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG56578

Eigenschaften

Anwendung: ICC, IF, IHC (paraffin), WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: Synthetic peptide around 14 aa (C-terminus) of Human IRF3
MW: 47 kD
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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