Anti-IKKbeta (IkappaB Kinase beta, IKKb, IKK2)

Anti-IKKbeta (IkappaB Kinase beta, IKKb, IKK2)
Anti-IKKbeta (IkappaB Kinase beta, IKKb, IKK2)
   
+ Gratis T-Shirt
Aktion:

Sichern Sie sich ein gratis "Stronger Bands" T-Shirt zu jeder Rockland-Bestellung >300 €.

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
100-401-220 100 µl - -

1 - 9 Werktage

493,00 €
 
Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway... mehr
Produktinformationen "Anti-IKKbeta (IkappaB Kinase beta, IKKb, IKK2)"
Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. [The UniProt Consortium]
Schlagworte: Anti-IKK2, Anti-IKKB, Anti-IkBKB, Anti-IKBKB, Anti-IKK-B, Anti-NFKBIKB, Anti-IKK-beta, EC=2.7.11.10, Anti-I-kappa-B kinase 2, Anti-I-kappa-B-kinase beta, Anti-Nuclear factor NF-kappa-B inhibitor kinase beta
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 100-401-220

Eigenschaften

Anwendung: IP, WB, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Rat, Mouse
Immunogen: synthetic peptide corresponding to the CT of human IKKbeta
MW: 87 kD
Format: Serum

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-IKKbeta (IkappaB Kinase beta, IKKb, IKK2)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen