Zu "K07209" wurden 116 Artikel gefunden!
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Mouse IKKB (Inhibitor of kappa B Kinase Beta) ELISA Kit
Artikelnummer: ELK-ELK0724.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse IKKB. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse IKKB. Next,...
| Schlagworte: | IKK2, Ikkb, IkBKB, Ikbkb, IKK-B, NFKBIKB, IKK-beta, I-kappa-B kinase 2, I-kappa-B-kinase beta, Serine/threonine protein... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
BMS 345541 (hydrochloride)
Artikelnummer: Cay16667-1
BMS 345541 is a cell permeable inhibitor of the IkappaB kinases IKKalpha and IKKbeta (IC50s = 4 and 0.3 µM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM. BMS 345541 inhibits signaling through nuclear factor-kappaB (NF-kappaB) both in cells and in vivo, showing...
| Schlagworte: | IKK Inhibitor III, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, bis(2,2,2-trifluoroacetate) |
| Anwendung: | Cell permeable IKK-alpha/beta inhibitor |
| CAS | 547757-23-3 |
| MW: | 291.8 D |
ab 60,00 €
COVID-19 Forschung
Auranofin
Artikelnummer: AG-CR1-3611-M025
White to off-white solid. Soluble in DMSO or 100% ethanol. Insoluble in water. Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway, Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5, Potent thioredoxin...
| Schlagworte: | 1-Thio-beta-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetra- acetate, NSC 321521, SKF 39162 |
| Anwendung: | Antiinflammatory agent |
| CAS | 34031-32-8 |
| MW: | 678,5 D |
ab 61,00 €
IKK-16 (hydrochloride)
Artikelnummer: Cay13313-5
IKK-16 is a potent inhibitor of IkappaB kinases (IKKs), displaying IC50 values of 200, 40, and 70 nM for IKKalpha, IKKbeta, and IKK complex, respectively, in cell-free assays. It is effective in cells and in animals and has been used delineate the role of NF-kappaB signaling in diverse contexts. IKK-16 has also been...
| Schlagworte: | IKK Inhibitor VII, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone,... |
| Anwendung: | IkappaB kinase inhibitor |
| CAS | 1186195-62-9 |
| MW: | 520.1 D |
ab 125,00 €
BI-605906
Artikelnummer: Cay19184-1
BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit beta (IKKbeta, IC50 = 380 nM). It is selective for IKKbeta over insulin-like growth factor 1 (IGF1, IC50 = 7.6 µM) and over 100 kinases in a panel up to 10 µM. BI-605906 partially inhibits IL-1-stimulated activation of IKKepsilon/TBK1 in vitro....
| Schlagworte: | 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-thieno[2,3-b]pyridine-2-carboxamide |
| Anwendung: | IKK beta inhibitor |
| CAS | 960293-88-3 |
| MW: | 432.5 D |
ab 102,00 €
SC-514
Artikelnummer: Cay10010267-10
SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6,...
| Schlagworte: | 4-amino-[2,3'-bithiophene]-5-carboxamide |
| Anwendung: | IKK2 inhibitor |
| CAS | 354812-17-2 |
| MW: | 224.3 D |
ab 60,00 €
Anti-IKKbeta, clone 10AG2
Artikelnummer: 200-301-H83
Anti-IKKbeta Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with IKKbeta from Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity withAnti-IKKbeta from other sources has not been determined. Protein function: Serine kinase...
| Schlagworte: | Anti-IKK2, Anti-IKKB, Anti-IKBKB, Anti-IKK-B, Anti-IkBKB, Anti-NFKBIKB, Anti-IKK-beta, EC=2.7.11.10, Anti-I-kappa-B kinase... |
| Anwendung: | FC, IHC, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse |
791,00 €
IMD 0354
Artikelnummer: Cay17290-1
IMD 0354 is an IKKbeta (IKK2) inhibitor that blocks NF-kappaB phosphorylation (IC50 = ~250 nM) and subsequent NF-kappaB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1beta and MCP-1 production,...
| Schlagworte: | IKK2 Inhibitor V, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide |
| Anwendung: | IKK2 inhibitor |
| CAS | 978-62-1 |
| MW: | 383.7 D |
ab 50,00 €
TPCA-1
Artikelnummer: Cay15115-10
TPCA-1 is a selective inhibitor of IkappaB kinase-2 (IC50s = 17.9 nM and 0.40 µM for IKK2 and IKK1, respectively). Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK. TPCA-1 inhibits the production of LPS-induced TNF-alpha, IL-6, and IL-8 with...
| Schlagworte: | IKK2 Inhibitor IV, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide |
| Anwendung: | IkappaB kinase-2 inhibitor |
| CAS | 507475-17-4 |
| MW: | 279.3 D |
ab 92,00 €
ACHP
Artikelnummer: Cay14504-1
ACHP is an inhibitor of IkappaB kinase beta (IKKbeta) and IKKalpha (IC50s = 8.5 and 250 nM, respectively). It is selective for IKKbeta and IKKalpha over IKKgamma, Syk, and MKK4 (IC50s = >20 µM for all). It reduces the constitutive phosphorylation of IkappaBalpha and NF-kappaB p65 in U266 and NCU-MM-2 multiple...
| Schlagworte: | 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile |
| Anwendung: | IKKbeta / IKKalpha inhibitor |
| CAS | 406208-42-2 |
| MW: | 364.4 D |
ab 92,00 €
Anti-IKK-beta
Artikelnummer: A301-827A
Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of...
| Schlagworte: | Anti-IKK2, Anti-IKKB, Anti-IKK-B, Anti-IKBKB, Anti-IkBKB, Anti-NFKBIKB, Anti-IKK-beta, EC=2.7.11.10, Anti-I-kappa-B kinase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
PS-1145
Artikelnummer: Cay14862-1
PS-1145 is an IkappaB kinase beta (IKKbeta) inhibitor (IC50 = 88 nM). It selectively inhibits IKKbeta over a panel of 14 kinases (IC50s = >100 nM for all). PS-1145 also inhibits the IKK complex (IC50 = 100 nM). It inhibits the proliferation of MM.1S, U266, and RPMI-8226 myeloma cells when used at concentrations...
| Schlagworte: | IKK Inhibitor X, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide |
| Anwendung: | IKKbeta inhibitor |
| CAS | 431898-65-6 |
| MW: | 322.8 D |
ab 43,00 €