Zu "K07209" wurden 117 Artikel gefunden!
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BMS 345541 (hydrochloride)
Artikelnummer: Cay16667-1
BMS 345541 is a cell permeable inhibitor of the IkappaB kinases IKKalpha and IKKbeta (IC50s = 4 and 0.3 µM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM. BMS 345541 inhibits signaling through nuclear factor-kappaB (NF-kappaB) both in cells and in vivo, showing...
| Schlagworte: | IKK Inhibitor III, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, bis(2,2,2-trifluoroacetate) |
| Anwendung: | Cell permeable IKK-alpha/beta inhibitor |
| CAS | 547757-23-3 |
| MW: | 291.8 D |
ab 67,00 €
COVID-19 Forschung
Auranofin
Artikelnummer: AG-CR1-3611-M025
White to off-white solid. Soluble in DMSO or 100% ethanol. Insoluble in water. Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway, Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5, Potent thioredoxin...
| Schlagworte: | 1-Thio-beta-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetra- acetate, NSC 321521, SKF 39162 |
| Anwendung: | Antiinflammatory agent |
| CAS | 34031-32-8 |
| MW: | 678,5 D |
ab 66,00 €
IKK-16 (hydrochloride)
Artikelnummer: Cay13313-5
IKK-16 is a potent inhibitor of IkappaB kinases (IKKs), displaying IC50 values of 200, 40, and 70 nM for IKKalpha, IKKbeta, and IKK complex, respectively, in cell-free assays. It is effective in cells and in animals and has been used delineate the role of NF-kappaB signaling in diverse contexts. IKK-16 has also been...
| Schlagworte: | IKK Inhibitor VII, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone,... |
| Anwendung: | IkappaB kinase inhibitor |
| CAS | 1186195-62-9 |
| MW: | 520.1 D |
ab 139,00 €
BI-605906
Artikelnummer: Cay19184-1
BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit beta (IKKbeta, IC50 = 380 nM). It is selective for IKKbeta over insulin-like growth factor 1 (IGF1, IC50 = 7.6 µM) and over 100 kinases in a panel up to 10 µM. BI-605906 partially inhibits IL-1-stimulated activation of IKKepsilon/TBK1 in vitro....
| Schlagworte: | 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-thieno[2,3-b]pyridine-2-carboxamide |
| Anwendung: | IKK beta inhibitor |
| CAS | 960293-88-3 |
| MW: | 432.5 D |
ab 114,00 €
SC-514
Artikelnummer: TGM-T2118-5mg
Description: SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 µM), obstructs NF-kappaB-dependent gene expression. Target: IkappaB/IKK, p38 MAPK, CDK, Aurora Kinase, Serine Protease. Smiles: NC(=O)c1sc(cc1N)-c1ccsc1. References: Kishore N, et al. J Biol Chem, 2003,...
| Schlagworte: | GK 01140 |
| Anwendung: | IKK2 inhibitor |
| CAS | 354812-17-2 |
| MW: | 224.3 D |
ab 30,00 €
SC-514
Artikelnummer: Cay10010267-10
SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6,...
| Schlagworte: | 4-amino-[2,3'-bithiophene]-5-carboxamide |
| Anwendung: | IKK2 inhibitor |
| CAS | 354812-17-2 |
| MW: | 224.3 D |
ab 52,00 €
Anti-IKKbeta, clone 10AG2
Artikelnummer: 200-301-H83
Anti-IKKbeta Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with IKKbeta from Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity withAnti-IKKbeta from other sources has not been determined. Protein function: Serine kinase...
| Schlagworte: | Anti-IKK2, Anti-IKKB, Anti-IKBKB, Anti-IKK-B, Anti-IkBKB, Anti-NFKBIKB, Anti-IKK-beta, EC=2.7.11.10, Anti-I-kappa-B kinase... |
| Anwendung: | FC, IHC, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse |
819,00 €
PS-1145
Artikelnummer: Cay14862-1
PS-1145 is an IkappaB kinase beta (IKKbeta) inhibitor (IC50 = 88 nM). It selectively inhibits IKKbeta over a panel of 14 kinases (IC50s = >100 nM for all). PS-1145 also inhibits the IKK complex (IC50 = 100 nM). It inhibits the proliferation of MM.1S, U266, and RPMI-8226 myeloma cells when used at concentrations...
| Schlagworte: | IKK Inhibitor X, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide |
| Anwendung: | IKKbeta inhibitor |
| CAS | 431898-65-6 |
| MW: | 322.8 D |
ab 49,00 €
IMD 0354
Artikelnummer: Cay17290-1
IMD 0354 is an IKKbeta (IKK2) inhibitor that blocks NF-kappaB phosphorylation (IC50 = ~250 nM) and subsequent NF-kappaB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1beta and MCP-1 production,...
| Schlagworte: | IKK2 Inhibitor V, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide |
| Anwendung: | IKK2 inhibitor |
| CAS | 978-62-1 |
| MW: | 383.7 D |
ab 56,00 €
TPCA-1
Artikelnummer: Cay15115-1
TPCA-1 is a selective inhibitor of IkappaB kinase-2 (IC50s = 17.9 nM and 0.40 µM for IKK2 and IKK1, respectively). Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK. TPCA-1 inhibits the production of LPS-induced TNF-alpha, IL-6, and IL-8 with...
| Schlagworte: | IKK2 Inhibitor IV, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide |
| Anwendung: | IkappaB kinase-2 inhibitor |
| CAS | 507475-17-4 |
| MW: | 279.3 D |
ab 102,00 €
ACHP
Artikelnummer: Cay14504-1
ACHP is an inhibitor of IkappaB kinase beta (IKKbeta) and IKKalpha (IC50s = 8.5 and 250 nM, respectively). It is selective for IKKbeta and IKKalpha over IKKgamma, Syk, and MKK4 (IC50s = >20 µM for all). It reduces the constitutive phosphorylation of IkappaBalpha and NF-kappaB p65 in U266 and NCU-MM-2 multiple...
| Schlagworte: | 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile |
| Anwendung: | IKKbeta / IKKalpha inhibitor |
| CAS | 406208-42-2 |
| MW: | 364.4 D |
ab 102,00 €
TPCA-1
Artikelnummer: TGM-T3049-2mg
Description: TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM), shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes. Target: Apoptosis, IkappaB/IKK, STAT. Smiles: NC(=O)Nc1sc(cc1C(N)=O)-c1ccc(F)cc1. References: Podolin PL, et al, J Pharmacol Exp...
| Schlagworte: | IKK2 Inhibitor IV, TPCA1, GW683965 |
| Anwendung: | IkappaB kinase-2 inhibitor |
| CAS | 507475-17-4 |
| MW: | 279.29 D |
ab 37,00 €