Zu "K07209" wurden 119 Artikel gefunden!
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BMS-345541 hydrochloride
Artikelnummer: TGM-T8542-100mg
Description: BMS-345541 hydrochloride is a selective IKK inhibitor, targeting IKK2 and IKK1 with IC50 values of 0.3 µM and 4 µM, respectively. Target: IkappaB/IKK. Smiles: Cl.Cc1cnc2c(NCCN)nc3ccc(C)cc3n12. References: Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma:...
| Anwendung: | Cell permeable IKK-alpha/beta inhibitor |
| CAS | 547757-23-3 |
| MW: | 291.78 D |
ab 34,00 €
IKBKB Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01531-100ug
Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B...
| Schlagworte: | Inhibitor of nuclear factor kappa-B kinase subunit beta, IKBKB, Nuclear factor NF-kappa-B inhibitor kinase beta,... |
| MW: | 89.1 kD |
ab 491,00 €
IKBKB Protein, Human, Recombinant (E. coli, His)
Artikelnummer: TGM-TMPH-01532-100ug
Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B...
| Schlagworte: | Serine/threonine protein kinase IKBKB, I-kappa-B kinase 2, Inhibitor of nuclear factor kappa-B kinase subunit beta, IKBKB,... |
| MW: | 92.5 kD |
ab 281,00 €
MLN120B
Artikelnummer: TGM-TQ0306-100mg
Description: MLN120B is a selective and ATP competitive IKKbeta inhibitor (IC50: 60 nM). Target: IkappaB/IKK. Smiles: COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C. References: Hideshima T, et all. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer...
| Anwendung: | IKKbeta inhibitor |
| CAS | 783348-36-7 |
| MW: | 366.8 D |
ab 45,00 €
AZD3264
Artikelnummer: TGM-T6771-100mg
Description: AZD3264 is a new type IKK2 inhibitor. Target: IkappaB/IKK. Smiles: Cc1noc(C)c1-c1ccc(-c2cc(C(N)=O)c(NC(N)=O)s2)c(O[C@H]2CCNC2)c1. References: Murugan A, et al. Org. Process Res. Dev. 2014, 18, 646-651.
| Anwendung: | IKK2 Inhibitor |
| CAS | 1609281-86-8 |
| MW: | 441.5 D |
ab 45,00 €
IMD-0354
Artikelnummer: TGM-T6141-100mg
Description: IMD-0354 (IKK2 Inhibitor V) is an IKKbeta inhibitor that blocks IkappaBalpha phosphorylation in the NF-kappaB pathway. Target: IkappaB/IKK. Smiles: Oc1ccc(Cl)cc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F. References: Tanaka A, et al. Blood, 2005, 105(6), 2324-2331.
| Schlagworte: | IMD 0354, IKK2 Inhibitor V |
| Anwendung: | IKK2 inhibitor |
| CAS | 978-62-1 |
| MW: | 383.67 D |
ab 42,00 €
PHA-408
Artikelnummer: Cay41279-1
PHA-408 is an inhibitor of IkappaB kinase beta (IKKbeta, IC50 = 0.04 µM). It is selective for IKKbeta over IKKalpha, Pim-1, Pim-2, Tie2, TrkA, and p70S6K (IC50s = 0.6-28.4 µM), as well as a panel of 26 kinases (IC50s = >30 µM for all). PHA-408 inhibits IL-1beta-induced production of prostaglandin E2 (PGE2,...
| Schlagworte: | PHA-767408,... |
| Anwendung: | IKKbeta inhibitor |
| CAS | 503555-55-3 |
| MW: | 560 D |
ab 39,00 €
IKK 16 hydrochloride
Artikelnummer: TGM-T15557-100mg
Description: IKK 16 hydrochloride is a selective inhibitor of IKK2 (IC50: 40 nM), the IKK complex (IC50: 70 nM), and IKK1 IkappaB kinase (IKK) (IC50: 200 nM), as well as leucine-rich repeat kinase-2 (LRRK2, IC50: 50 nM). Target: Others. Smiles: Cl.O=C(NN1CCC(CC1)N1CCCC1)c1ccc(Nc2nccc(n2)-c2cc3ccccc3s2)cc1....
| Anwendung: | IkappaB kinase inhibitor |
| CAS | 1186195-62-9 |
| MW: | 520.09 D |
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BI605906
Artikelnummer: TGM-T14567-100mg
Description: BI605906 is an IKKbeta inhibitor that inhibits tumor necrosis factor alpha-dependent IkappaB degradation and expression of the pro-inflammatory mediator interleukin-6, which can be used to study inflammatory skin diseases such as psoriasis. Target: IkappaB/IKK, IL Receptor. Smiles:...
| Schlagworte: | BI 605906, BI-605906 |
| Anwendung: | IKK beta inhibitor |
| CAS | 960293-88-3 |
| MW: | 432.51 D |
ab 31,00 €
SC-514
Artikelnummer: TGM-T2118-100mg
Description: SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 µM), obstructs NF-kappaB-dependent gene expression. Target: IkappaB/IKK, p38 MAPK, CDK, Aurora Kinase, Serine Protease. Smiles: NC(=O)c1sc(cc1N)-c1ccsc1. References: Kishore N, et al. J Biol Chem, 2003,...
| Schlagworte: | GK 01140 |
| Anwendung: | IKK2 inhibitor |
| CAS | 354812-17-2 |
| MW: | 224.3 D |
ab 31,00 €
PHA-408
Artikelnummer: TGM-T24629-100mg
Description: PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2. Target: Others. Smiles: CN1CCN(CC1)c1cc(C(=O)Nc2ccc3CCc4c(nn(c4-c3c2)-c2ccc(F)cc2)C(N)=O)c(Cl)cn1. References: Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH. Natural Modulators of Endosomal Toll-Like Receptor-Mediated...
| Schlagworte: | PHA 408 |
| Anwendung: | IKKbeta inhibitor |
| CAS | 503555-55-3 |
| MW: | 560.02 D |
ab 1.520,00 €
LY2409881 trihydrochloride
Artikelnummer: TGM-T2081-1mg
Description: LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM), IC50 for IKK1 and other common kinases is at least one log higher. Target: IkappaB/IKK, Apoptosis. Smiles: Cl.Cl.Cl.CN1CCN(CCCNc2ncc(Cl)c(n2)-c2cc3c(cccc3s2)C(=O)NC2CC2)CC1. References: Deng C, et al. Clin Cancer Res. 2015,...
| Schlagworte: | LY2409881 |
| Anwendung: | IKK2 inhibitor |
| CAS | 946518-60-1 |
| MW: | 594.43 D |
ab 45,00 €