Anti-hyl-2

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: Catalyzes the acylation of sphingoid bases to form ceramides, which are key players in cell signaling events such as tolerances to heat, oxidation, and ultraviolet stress (PubMed:19372430, PubMed:38677510). C.elegans contain specific sphingoid bases, which are unique or different in structure compared to the sphingoid bases found in other animals. Two examples of these distinctive compounds are: 15- methylhexadecasphinganine and 15-methylhexadecasphing-4-enine (PubMed:30155209). Exhibits substrate preference for long and very long fatty acyl-coA chains (C20-23) (PubMed:19372430, PubMed:38677510). Required for adaptation of the nematode to anoxia (PubMed:19372430). Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by HYL-2, and seems to be affected by a pathway that is parallel to that involving daf-2 (Probable). [The UniProt Consortium]