Anti-Human MIP-3?, clone 3N2D9

Anti-MIP-3? was purified from clarified mouse ascetic fluid by Protein A chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for human MIP-3? protein. A BLAST analysis was used to suggest cross-reactivity with MIP-3? from human sources based on 100% homology with the immunizing sequence. Cross-reactivity with MIP-3? from other sources has not been determined. Protein function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. [The UniProt Consortium]