Anti-Histone H4K8Ac Monoclonal Antibody (RM201)

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Acetylation of histone H4 at lysine 8 (H4K8Ac) is associated with transcriptional activation and mediates recruitment of SWI/SNF chromatin remodeling complexes. P. falciparum schizonts expressing a lysine-to-arginine substitution at Lys8 in histone 4, which prevents its acetylation, have increased multiplication rates. Tumor H4K8Ac levels are increased in patients with breast cancer. Cayman's Histone H4K8Ac Monoclonal Antibody (RM201) can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.Synonyms: Acetylated Histone H4 Lysine 8. Immunogen: Peptide corresponding to H4K8Ac. Clone Designation: RM201. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% Glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ChIP, ELISA, ICC, multiplex-based assays, and WB. Cross Reactivity: (+) H4K8Ac, (-) Unmodified H4K8, (-) H4K5Ac, (-) H4K12Ac, (-) H4K16Ac, (-) H4K20Ac, (-) H4K31Ac, (-) H4K91Ac.