Anti-HDAC6

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the epsilon-amino groups of lysines located near the amino termini of core histone proteins. Eleven members of the HDAC family have been identified in the past several years. These HDAC family members are divided into two classes, I and II. HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.Synonyms: Histone Deacetylase 6. Immunogen: synthetic peptide corresponding to amino acids 1-16 of human HDAC-6. Formulation: (Request formulation change), 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Host: Rabbit. Isotype: IgG. Applications: WB, IP, and ChIP. Origin: Animal/Rabbit.