Zu "K11407" wurden 119 Artikel gefunden!
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HDAC-6, active human recombinant protein
Artikelnummer: BPS-50006
Active human HDAC6, GenBank Accession No. BC069243, full length with N-terminal GST tag, MW= 159 kDa, expressed in baculovirus expression system.
| Schlagworte: | HD6, JM21, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 159 kD |
781,00 €
J27644
Artikelnummer: Cay39469-1
J27644 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 10 nM). It is selective for HDAC6 over HDAC1-5 (IC50s = 211-516 nM) and HDAC7, -8, -9, and -11 (IC50s = 137-812 nM). J27644 (10 µM) reduces the level of proteins involved in fibrosis, including collagen 1A1, alpha-smooth muscle actin (alpha-SMA), and...
| Schlagworte: | 4-((8-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl)-N-hydroxybenzamide |
| Anwendung: | HDAC6 inhibitor |
| MW: | 345.7 D |
ab 340,00 €
Human HDAC6 (Histone Deacetylase 6) ELISA Kit
Artikelnummer: ELK-ELK3698.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HDAC6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HDAC6. Next,...
| Schlagworte: | HD6, JM21, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Mouse HDAC6 (Histone Deacetylase 6) ELISA Kit
Artikelnummer: ELK-ELK7058.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse HDAC6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse HDAC6. Next,...
| Schlagworte: | HD6, Histone deacetylase 6, Histone deacetylase mHDA2, Tubulin-lysine deacetylase HDAC6 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Tubacin
Artikelnummer: Cay13691-1
Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM). In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 µM). Tubacin induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical...
| Schlagworte: | N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy... |
| Anwendung: | Tubulin acetylation inducer, HDAC6 inhibitor |
| CAS | 537049-40-4 |
| MW: | 721.9 D |
ab 142,00 €
Sulforaphane
Artikelnummer: Cay10496-5
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective...
| Schlagworte: | SFN, 1-isothiocyanato-4-(methylsulfinyl)-butane |
| Anwendung: | HDAC inhibitor, chemopreventive agent |
| CAS | 4478-93-7 |
| MW: | 177.3 D |
ab 56,00 €
Anti-HDAC6
Artikelnummer: A301-342A
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...
| Schlagworte: | Anti-HD6, Anti-JM21, Anti-HDAC6, Anti-KIAA0901, EC=3.5.1.98, Anti-Histone deacetylase 6 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
HDAC6, GST-Tag (Rat) Recombinant
Artikelnummer: BPS-101332
Recombinant rat full length HDAC6 (Histone Deacetylase 6) encompassing amino acids 1-1152(end). The construct contains a N- terminal GST-Tag. This protein was affinity purified
| Schlagworte: | Histone deacetylase 6, HDAC6(GST-1-1152(end)) |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Ursprungsart: | rat |
| MW: | 156 kD |
650,00 €
Fluorogenic Rat HDAC6 Assay Kit
Artikelnummer: BPS-78849
The rat histone deacetylase 6 (HDAC6) Assay Kit is a 96-well fluorogenic assay designed to measure rat HDAC6 enzymatic activity for screening and profiling applications. In addition, the kit includes a potent HDAC inhibitor, Trichostatin A (TSA), for use as control. The Fluorogenic Rat HDAC6 Assay Kit is based on a...
| Schlagworte: | Histone deacetylase 6, |
| Anwendung: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | rat |
840,00 €
CAY10603
Artikelnummer: Cay13146-1
Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with...
| Schlagworte: | HDAC 6 inhibitor, Histone Deacetylase Inhibitor VIII,... |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1045792-66-2 |
| MW: | 446.5 D |
ab 65,00 €
Tubastatin A
Artikelnummer: Cay15785-5
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a...
| Schlagworte: | N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-benzamide |
| Anwendung: | Potent HDAC6 inhibitor |
| CAS | 1252003-15-8 |
| MW: | 335.4 D |
ab 60,00 €
HDAC-6 (FLAG-tag), active human recombinant protein
Artikelnummer: BPS-50056
Human HDAC6 (GenBank Accession No. NM_006044), full length with C-terminal Flag tag, MW= 132 kDa, expressed in baculovirus expression system. Protein was purified by affinity chromatography and gel filtration. Assay condition: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 µM BPS...
| Schlagworte: | HD6, JM21, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 132 kD |
730,00 €