Zu "K11407" wurden 165 Artikel gefunden!
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HDAC-6, active human recombinant protein
Artikelnummer: BPS-50006
Active human HDAC6, GenBank Accession No. BC069243, full length with N-terminal GST tag, MW= 159 kDa, expressed in baculovirus expression system.
| Schlagworte: | HD6, JM21, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 159 kD |
797,00 €
NEU
Mz325
Artikelnummer: Cay45518-1
Mz325 is a dual inhibitor of histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2, IC50s = 0.043 and 0.32 µM, respectively, in a cell-free assay). Mz325 is a heterobifunctional molecule that contains an HDAC6 inhibitor conjugated to a SIRT2 inhibitor via a triazole linker. It is selective for HDAC6 and SIRT2 over...
| Schlagworte: | N-butyl-4-[[3-[[2-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]-5-thiazolyl]methyl]phenoxy]methyl]-N-[[4-[(hydroxyam... |
| Anwendung: | HDAC6 / SIRT2 dual inhibitor |
| CAS | 3032670-12-2 |
| MW: | 771.96 D |
ab 55,00 €
MPT0G211
Artikelnummer: Cay43666-1
MPT0G211 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 0. nM). It is selective for HDAC6 over HDAC1-5 (IC50s = 9. 12. 7. 4. and 3. µM, respectively), HDAC7-11 (IC50s = 0. 1. 1. 9. and 0. µM, respectively), and sirtuin 1 (SIRT1, IC50 = > 20 µM), as well as a panel of 97 kinases at 1 µM. MPT0G211 inhibits...
| Schlagworte: | N-hydroxy-4-[(8-quinolinylamino)methyl] benzamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 2151853-97-1 |
| MW: | 293.33 D |
ab 91,00 €
Sulforaphane
Artikelnummer: Cay10496-5
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective...
| Schlagworte: | SFN, 1-isothiocyanato-4-(methylsulfinyl)-butane |
| Anwendung: | HDAC inhibitor, chemopreventive agent |
| CAS | 4478-93-7 |
| MW: | 177.3 D |
ab 59,00 €
Anti-HDAC6
Artikelnummer: A301-342A
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...
| Schlagworte: | Anti-HD6, Anti-JM21, Anti-HDAC6, Anti-KIAA0901, EC=3.5.1.98, Anti-Histone deacetylase 6 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
CAY10603
Artikelnummer: Cay13146-1
Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with...
| Schlagworte: | HDAC 6 inhibitor, Histone Deacetylase Inhibitor VIII,... |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1045792-66-2 |
| MW: | 446.5 D |
ab 74,00 €
ACY-1083
Artikelnummer: Cay30505-1
An HDAC6 inhibitor (IC50 = 3 nM), increases the levels of acetylated alpha-tubulin in SK-N-BE(2) cells in a concentration-dependent manner, prevents cisplatin-induced decreases in mitochondrial OCR and mitochondrial motility in tibial nerves isolated from mice at 10 mg/kg per day, inhibits cisplatin-induced...
| Schlagworte: | 2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxy-5-pyrimidinecarboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1708113-43-2 |
| MW: | 348.4 D |
ab 198,00 €
HDAC-6 (FLAG-tag), active human recombinant protein
Artikelnummer: BPS-50056
Human HDAC6 (GenBank Accession No. NM_006044), full length with C-terminal Flag tag, MW= 132 kDa, expressed in baculovirus expression system. Protein was purified by affinity chromatography and gel filtration. Assay condition: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 µM BPS...
| Schlagworte: | HD6, JM21, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 132 kD |
745,00 €
ACY-1215
Artikelnummer: Cay21531-25
ACY-1215 is an inhibitor of the class IIb histone deacetylase (HDAC) HDAC6 (IC50 = 0.0047 µM). It is selective for HDAC6 over the class I HDACs HDAC1, -2, -3, and -8 (IC50s = 0.058, 0.048, 0.051, and 0.1 µM, respectively), class IIa HDACs HDAC4, -5, -7, and -9 (IC50s = 7, 5, 1.4 and >10 µM, respectively), class III...
| Schlagworte: | ACY-63, Ricolinostat, Rocilinostat, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1316214-52-4 |
| MW: | 433.5 D |
ab 112,00 €
HDAC6 (human, recombinant)
Artikelnummer: Cay10009465-1
HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological...
| Schlagworte: | HD6, HD6, JM21, Histone deacetylase 6, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6, Tubulin-lysine deacetylase... |
| Anwendung: | Enzyme activity |
| MW: | 159 kD |
834,00 €
HDAC6 Fluorogenic Assay kit
Artikelnummer: BPS-50076-1
The Fluorogenic HDAC3 Assay Kit is a complete assay system designed to measure HDAC6 activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent HDAC6 activity measurements. In addition, the kit includes purified HDAC6 enzyme and the...
| Schlagworte: | HD6, JM21, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6, |
| Anwendung: | HDAC6 activity screening |
ab 938,00 €
Sulforaphane
Artikelnummer: TGM-TQ0207-25mg
Description: Sulforaphane is a natural isothiocyanate that activates Nrf2 and inhibits AMPK-dependent signaling. Sulforaphane has antitumor and anti-inflammatory activities by increasing the transcription of tumor suppressor proteins and inhibiting histone deacetylase activity. Target: Nrf2, HDAC, Apoptosis....
| Anwendung: | HDAC inhibitor, chemopreventive agent |
| CAS | 4478-93-7 |
| MW: | 177.29 D |
ab 30,00 €