Anti-HDAC1 (IHC)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
IHC-00056-T 10 µl (2500 ng) -

2 - 8 Werktage*

164,00 €
IHC-00056 100 µl (25 µg) -

2 - 8 Werktage*

623,00 €
 
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of... mehr
Produktinformationen "Anti-HDAC1 (IHC)"
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. [The UniProt Consortium]
Schlagworte: Anti-HD1, Anti-HDAC1, Anti-RPD3L1, EC=3.5.1.98, Anti-Histone deacetylase 1
Hersteller: Bethyl Laboratories
Hersteller-Nr: IHC-00056

Eigenschaften

Anwendung: IHC, IHC-IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse (Erwartet: bovine, horse, rabbit, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, european domestic ferret, african elephant, chinese hamster, small-eared galago)
Immunogen: synthetic peptide. The epitope recognized by IHC-00056 maps to a region between residue 425 and the C-terminus (residue 482) of human Histone Deacetylase 1 using the numbering given in entry NP_004955.2 (GeneID 3065).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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