Anti-HDAC1

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the epsilon-amino groups of lysines located near the amino termini of core histone proteins. Eleven members of HDAC family have been identified in the past several years. These HDAC family members are divided into two classes, I and II. HDAC1 is a Class I HDAC which is related to the yeast HDAC Rpd3. It is primarily localized to the nucleus with ubiquitous distribution throughout human cell lines and tissues. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.Synonyms: Histone Deactylase 1. Immunogen: synthetic peptides corresponding to amino acids 1-5, 433-448 and 467-482 of human HDAC1. Formulation: (Request formulation change), 100 µg of protein G-purified IgG in 200 µl PBS containing 0.02% sodium azide. Host: Rabbit. Applications: WB. Origin: Animal/Rabbit.