Anti-FTO (Fat mass and obesity related protein), clone 5-2H10

Anti-FTO antibody is directed against human Fat mass and Obesity Related Protein. Anti-Fat mass and Obesity Related Protein is a Protein G purified antibody. Reactivity is expected with the following species based on 100% sequence homology: bovine, canine, horse, non-human primate, sheep. Protein function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. [The UniProt Consortium]