Zu "K19469" wurden 58 Artikel gefunden!
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Bisantrene
Artikelnummer: TGM-T4047-100mg
Description: Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but...
| Schlagworte: | CL216942 |
| Anwendung: | FTO inhibitor, antineoplastic |
| CAS | 78186-34-2 |
| MW: | 398.46 D |
ab 34,00 €
FB23-2
Artikelnummer: TGM-T7138-100mg
Description: FB23-2 is a potent and selective inhibitor of the mRNA N6-methyladenosine (m6A) demethylase FTO with an IC50 of 2.6 µM. Target: Apoptosis, Others. Smiles: Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(=O)NO)c(Cl)c1. References: Huang Y , Su R , Sheng Y , et al. Small-Molecule Targeting of Oncogenic FTO Demethylase...
| Anwendung: | FTO inhibitor |
| CAS | 2243736-45-8 |
| MW: | 392.24 D |
ab 33,00 €
FB23
Artikelnummer: TGM-T8874-100mg
Description: FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.). Target: Others. Smiles: Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(O)=O)c(Cl)c1. References: Small-molecule targeting of oncogenic FTO...
| Anwendung: | FTO inhibitor |
| CAS | 2243736-35-6 |
| MW: | 377.22 D |
ab 45,00 €
FTO Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-00920-100ug
Description: FTO Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
| Schlagworte: | U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, Alpha-ketoglutarate-dependent dioxygenase FTO, tRNA... |
| MW: | 65.7 kD |
ab 236,00 €
5-Aminofluorescein
Artikelnummer: TGM-T18889-1mL
Description: 5-Aminofluorescein (5-AF) (5-AF) is a covalently-bound fluorescence marker conjugated with human serum albumin. It exhibits an excitation wavelength of 490 nm and an emission wavelength of 515 nm. Target: Others. Smiles: NC1=CC2=C(C=C1)C1(OC2=O)C2=C(OC3=C1C=CC(O)=C3)C=C(O)C=C2. References: Ding R, et...
| Schlagworte: | 5-AF |
| Anwendung: | Fluorescent compound, FTO inhibitor |
| CAS | 3326-34-9 |
| MW: | 347.32 D |
ab 33,00 €
Bisantrene
Artikelnummer: Cay40986-10
Bisantrene is an inhibitor of fat mass and obesity-associated protein (FTO, IC50 = 142.6 nM in a cell-free assay). It decreases the viability of Mono-Mac-6, NOMO-1, U937, MV4-11, and ML-2 acute myeloid leukemia (AML) cells (IC50s = 58.9-175.9 nM), as well as increases the levels of N6-methyladenosine (m6A) in...
| Schlagworte: | Bisantrenum, 9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] 9,10-anthracenedicarboxaldehyde |
| Anwendung: | FTO inhibitor, antineoplastic |
| CAS | 78186-34-2 |
| MW: | 398.5 D |
ab 54,00 €
Anti-FTO
Artikelnummer: CSB-PA004640.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-m6A(m)-demethylase FTO, Anti-tRNA N1-methyl adenine demethylase FTO, Anti-Fat mass and obesity-associated protein,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-FTO
Artikelnummer: CSB-PA729928.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: FTO. Antigen Species: Human
| Schlagworte: | Anti-m6A(m)-demethylase FTO, Anti-tRNA N1-methyl adenine demethylase FTO, Anti-Fat mass and obesity-associated protein,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-FTO
Artikelnummer: CSB-PA958648.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: FTO. Antigen Species: Human
| Schlagworte: | Anti-m6A(m)-demethylase FTO, Anti-tRNA N1-methyl adenine demethylase FTO, Anti-Fat mass and obesity-associated protein,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO),...
Artikelnummer: CSB-EP880154HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-505aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI LREASSVSEE LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG NPGCTYKYLN...
| Schlagworte: | m6A(m)-demethylase FTO, tRNA N1-methyl adenine demethylase FTO, Fat mass and obesity-associated protein, mRNA... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 65.7 kD |
ab 247,00 €
Entacapone
Artikelnummer: AG-CR1-3708-M005
Potent FTO (fat mass and obesity-associated gene) inhibitor for in vivo studies. FTO belongs to the Fe2+ and alpha-ketoglutarate (alpha-KG)-dependent oxygenase family. It demethylates N6-adenosine-modified (m6A) sites and N6,2'-O-dimethyladenosine-modified (m6Am) sites of mRNA. With its demethylase activity, FTO...
| Schlagworte: | OR-611, (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide |
| Anwendung: | Potent FTO inhibitor (in vivo) |
| CAS | 130929-57-6 |
| MW: | 305.3 D |
ab 33,00 €
FTO Chemiluminescent Assay Kit
Artikelnummer: BPS-79344
The FTO Chemiluminescent Assay Kit is designed to measure FTO activity for screening and profiling applications. The key to the FTO Chemiluminescent Assay Kit is a highly specific antibody that recognizes methylated substrate. Signal is inversely related to the activity. With this kit, only three simple steps on a...
| Schlagworte: | ALKBH9, BMIQ14, |
| Anwendung: | Enzyme kinetics, HTS |
| Spezies-Reaktivität: | human |
1.204,00 €