Zu "K19469" wurden 51 Artikel gefunden!
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FB23
Artikelnummer: Cay37383-1
FB23 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 0.06 µM) and an active metabolite of FB23-2 (Cay-36606). It reduces the proliferation of NB4 and Mono-Mac-6 acute myeloid leukemia (AML) cells (IC50s = 44.8 and 23.6 µM, respectively).Formal...
| Schlagworte: | 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-benzoic acid |
| Anwendung: | FTO inhibitor |
| CAS | 2243736-35-6 |
| MW: | 377.2 D |
ab 44,00 €
FTO Chemiluminescent Assay Kit
Artikelnummer: BPS-79344
The FTO Chemiluminescent Assay Kit is designed to measure FTO activity for screening and profiling applications. The key to the FTO Chemiluminescent Assay Kit is a highly specific antibody that recognizes methylated substrate. Signal is inversely related to the activity. With this kit, only three simple steps on a...
| Schlagworte: | ALKBH9, BMIQ14, |
| Anwendung: | Enzyme kinetics, HTS |
| Spezies-Reaktivität: | human |
1.122,00 €
Entacapone
Artikelnummer: AG-CR1-3708-M005
Potent FTO (fat mass and obesity-associated gene) inhibitor for in vivo studies. FTO belongs to the Fe2+ and alpha-ketoglutarate (alpha-KG)-dependent oxygenase family. It demethylates N6-adenosine-modified (m6A) sites and N6,2'-O-dimethyladenosine-modified (m6Am) sites of mRNA. With its demethylase activity, FTO...
| Schlagworte: | OR-611, (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide |
| Anwendung: | Potent FTO inhibitor (in vivo) |
| CAS | 130929-57-6 |
| MW: | 305.3 D |
ab 33,00 €
FB23-2
Artikelnummer: Cay36606-5
FB23-2 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 2.6 µM). It reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s = 0.8 and 1.5 µM, respectively). FB23-2 increases m6A levels in isolated human bone marrow cells, as well as...
| Schlagworte: | 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy-benzamide |
| Anwendung: | FTO inhibitor |
| CAS | 2243736-45-8 |
| MW: | 392.2 D |
ab 85,00 €
Anti-FTO (human)
Artikelnummer: AG-25A-0084-C100
Recognizes human FTO. Detects a band of about 59kDa by Western blot. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes'mutation. An association between FTO genotype and type 2 diabetes has been...
| Schlagworte: | Fat Mass and Obesity-associated Protein, FATSO |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
182,00 €
Anti-FTO (mouse)
Artikelnummer: AG-25A-0089-C100
Recognizes mouse FTO. Detects a band of about 58kDa by Western blot. Weakly cross-reacts with human FTO. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes'mutation. An association between FTO genotype...
| Schlagworte: | Fat Mass and Obesity-associated Protein, FATSO |
| Anwendung: | ELISA, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
182,00 €
Anti-FTO, Internal
Artikelnummer: ARG64738.100
Protein function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or...
| Schlagworte: | Anti-Fto, Anti-Kiaa1752, EC=1.14.11.-, Anti-Protein fatso, Anti-Fat mass and obesity-associated protein,... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
784,00 €
FTO, His-Tag
Artikelnummer: BPS-79306
Human FTO, also known as Fat mass and obesity-associated protein, ALKBH9, BMIQ14, GDFD, KIAA1752, and alpha-ketoglutarate-dependent dioxygenase, GenBank Accession No. NM_001080432, a.a 32-505 (end), with N-terminal His-Tag and expressed in a E. coli cell expression system. MW = 56 kDa.
| Schlagworte: | m6A(m)-demethylase FTO, tRNA N1-methyl adenine demethylase FTO, Fat mass and obesity-associated protein, mRNA... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Ursprungsart: | human |
| MW: | 56 kD |
686,00 €
Anti-FTO (mouse) (Clone FT 62-6)
Artikelnummer: Cay10814-100
Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...
| Schlagworte: | Anti-Protein fatso, Anti-Protein fatso, Anti-m6A(m)-demethylase FTO, Anti-m6A(m)-demethylase FTO, Anti-tRNA N1-methyl... |
| Anwendung: | ELISA, IHC, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | mouse |
ab 352,00 €
Anti-FTO (mouse) (Clone FT 342-1)
Artikelnummer: Cay10815-100
Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...
| Schlagworte: | Fat Mass- and Obesity-associated Protein, alpha-Ketoglutarate-dependent Dioxygenase FTO |
| Anwendung: | ELISA, WB |
| Wirt: | Rat |
| Spezies-Reaktivität: | mouse, rat |
ab 352,00 €
Anti-FTO (human) (Clone FT 86-4)
Artikelnummer: Cay10816-100
Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...
| Schlagworte: | Fat Mass- and Obesity-associated Protein, alpha-Ketoglutarate-dependent Dioxygenase FTO |
| Anwendung: | ELISA, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
ab 352,00 €
Anti-FTO (Fat mass and obesity related protein), clone...
Artikelnummer: 200-301-D41
Anti-FTO antibody is directed against human Fat mass and Obesity Related Protein. Anti-Fat mass and Obesity Related Protein is a Protein G purified antibody. Reactivity is expected with the following species based on 100% sequence homology: bovine, canine, horse, non-human primate, sheep. Protein function:...
| Schlagworte: | Anti-FTO, Anti-KIAA1752, EC=1.14.11.-, Anti-Fat mass and obesity-associated protein, Anti-Alpha-ketoglutarate-dependent... |
| Anwendung: | IFM, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
698,00 €