Anti-FLNA

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-15040.20 20 µl -

7 - 16 Werktage*

71,00 €
E-AB-15040.60 60 µl -

7 - 16 Werktage*

143,00 €
E-AB-15040.120 120 µl -

7 - 16 Werktage*

238,00 €
E-AB-15040.200 200 µl -

7 - 16 Werktage*

396,00 €
 
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and... mehr
Produktinformationen "Anti-FLNA"
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene. Protein function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. [The UniProt Consortium]
Schlagworte: Anti-FLN, Anti-FLNA, Anti-FLN-A, Anti-ABP-280, Anti-Filamin-A, Anti-Filamin-1, Anti-Alpha-filamin, Anti-Non-muscle filamin, Anti-Actin-binding protein 280, Anti-Endothelial actin-binding protein, FLNA Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-15040

Eigenschaften

Anwendung: WB, IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: Recombinant protein of human FLNA
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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