Anti-FGF acidic

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG56708.50 50 µg - -

6 - 14 Werktage*

520,00 €
 
Protein function: Plays an important role in the regulation of cell survival, cell division,... mehr
Produktinformationen "Anti-FGF acidic"
Protein function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). [The UniProt Consortium]
Schlagworte: Anti-FGF1, Anti-aFGF, Anti-ECGF, Anti-FGFA, Anti-FGF-1, Anti-HBGF-1, Anti-Fibroblast growth factor 1, Anti-Endothelial cell growth factor, Anti-Heparin-binding growth factor 1, Anti-Acidic fibroblast growth factor
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG56708

Eigenschaften

Anwendung: ELISA, WB, FA (Neutr.), IHC (paraffin)
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: E.coli derived Recombinant Human FGF acidic.(MFNLPPGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SVGEVYIKST ETGQYLAMDT DGLLYGSQTP NEECLFLERL EENHYNTYIS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D)
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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