Anti-FFAR4 (GPR120) (Internal)

GPR120 is a G protein-coupled receptor (GPR) expressed in adipocytes and pro-inflammatory macrophages that is activated by long chain free fatty acids. The activation of GPR120 results in elevated calcium ions and activation of the ERK cascade. omega-3 Fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid initiate GPR120 signaling resulting in inhibition of lipopolysaccharide and TNF-alpha inflammatory signaling pathways in a beta-arrestin2/TAB1 dependant manner. The anti-inflammatory effects of GPR120 are indirectly involved with promoting insulin secretion. GPR120 also mediates free fatty acid induced apoptosis inhibition in the enteroendocrin cell line STC-1. Cayman's internal polyclonal antibody detects GPR120 in LoVo and PC3 cell lysates. The predicted size for GPR120 is 42.2 kDa and the observed size is approximately 40 kDa by western blot.Synonyms: Free Fatty Acid Receptor 4, G Protein-Coupled Receptor 120, GPR120, GPR129, O3FAR1, PGR4. Immunogen: Synthetic peptide from the internal region of human FFAR4 (GPR120). Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02 % sodium azide. Host: Rabbit. Applications: ELISA and WB.