Anti-FFAR2 (GPR43) (Internal)

GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate. GPR43 couples through the Pertussis toxin-sensitive Gi/o and the pertussis toxin-insensitive Gq protein families and its expression has been described in enteroendocrine cells and neutrophils. The activation of GPR43 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP. Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman's GPR43 (Internal) Polyclonal Antibody detects a 37 kDa band in cell lysates.Synonyms: Free Fatty Acid Receptor 2, G Protein-Coupled Receptor 43. Immunogen: peptide from the internal region of human GPR43. Formulation: (Request formulation change), Peptide affinity-purified IgG lyophilized from TBS, pH 7.4, containing 5 mg/ml BSA. Storage Buffer: TBS, pH 7.4, with 5 mg/ml BSA when reconstituted in 500 µl of deionized. Host: Rabbit. Applications: FC, IF, and WB. UniProt Accession #: O15552.