Anti-EphA2

Anti-EphA2
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-025A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A302-025A-M 100 µl (10 blots) -

3 - 9 Werktage

290,00 €
A302-025A 100 µl (20 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A... mehr
Produktinformationen "Anti-EphA2"
Protein function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. [The UniProt Consortium]
Schlagworte: Anti-ECK, Anti-EPHA2, EC=2.7.10.1, Anti-Epithelial cell kinase, Anti-Ephrin type-A receptor 2, Anti-Tyrosine-protein kinase receptor ECK
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-025A-T

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse (Erwartet: Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig_10141, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Chinese Hamster, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-025A-T maps to a region between residue 926 and 976 of human ephrin receptor A2 using the numbering given in entry NP_004422.2 (GeneID 1969).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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