Anti-Desmin, clone DES-82

0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS. Desmin belongs to the type III family of intermediate filaments, a class of cytoskeletal elements. The DES gene encodes a cytoskeletal protein found in smooth, cardiac, and heart muscles. Tidball(1992) found that Desmin was codistributed with actin thin filaments within the cellular processes of myotendinous junctions in frog skeletal muscle. DES gene contains 9 exons and spans about 8.4 kb. By in situ hybridization, Viegas-Pequignot et al.(1989) localized the gene to 2q35. Mutations are responsible for idiopathic dilated cardiomyopathy. Protein function: Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. [The UniProt Consortium]