Anti-CRM1

Anti-CRM1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A300-490A-T 10 µl (10 µg) -

2 - 8 Werktage*

164,00 €
A300-490A 100 µl (100 µg) -

2 - 8 Werktage*

588,00 €
 
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a... mehr
Produktinformationen "Anti-CRM1"
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. [The UniProt Consortium]
Schlagworte: Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog
Hersteller: Bethyl Laboratories
Hersteller-Nr: A300-490A

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: zebrafish, X. laevis, X. tropicalis, chicken, turkey, bovine, dog, horse, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, west indian ocean coelacanth, duckbill platypus, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by A300-490A-T maps to a region between residues 375 and 425 of human Chromosome Region Maintenance 1 (Exportin 1) using the numbering given in entry NP_003391.1 (GeneID 7514).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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