Zu "K14290" wurden 32 Artikel gefunden!
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Human XPO1 (Exportin 1) ELISA Kit
Artikelnummer: ELK-ELK4663.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human XPO1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human XPO1. Next,...
| Schlagworte: | Exp1, XPO1, CRM1, Exportin-1, Chromosome region maintenance 1 protein homolog |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Leptomycin B
Artikelnummer: Cay10004976-5
Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear...
| Schlagworte: | Elactocin, LMB, Mantuamycin, NSC 364372,... |
| Anwendung: | Nuclear export blocker |
| CAS | 87081-35-4 |
| MW: | 540.7 D |
ab 48,00 €
Anti-CRM1
Artikelnummer: A300-469A
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this...
| Schlagworte: | Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Verdinexor
Artikelnummer: Cay26171-1
Verdinexor is a reversible inhibitor of Exportin I (XPO1/CRM1) with anticancer and antiviral activities. It inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively). Verdinexor inhibits XPO1/CRM1-mediated nuclear transport of...
| Schlagworte: | KPT-335, (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid, 2-(2-pyridinyl)hydrazide |
| Anwendung: | Nuclear export inhibitor, XPO1/CRM1 inhibitor |
| CAS | 1392136-43-4 |
| MW: | 442.3 D |
ab 39,00 €
KPT-276
Artikelnummer: Cay29158-5
KPT-276 is an orally bioavailable inhibitor of Exportin 1 (XPO1/CRM1) with anticancer activity. In vivo, KPT-276 (150 mg/kg) increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia (AML) mouse xenograft model. It also reduces tumor volume and increases survival in...
| Schlagworte: | (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-2-propen-1-one |
| Anwendung: | Exportin 1 (XPO1/CRM1) inhibitor, antineoplastic |
| CAS | 1421919-75-6 |
| MW: | 426.3 D |
ab 92,00 €
Anti-CRM1
Artikelnummer: A300-490A
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this...
| Schlagworte: | Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-CRM1
Artikelnummer: NSJ-R32412
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is an eukaryotic protein that mapped to human chromosome 2p16 by fluorescence in situ hybridization. This protein mediates leucine-rich nuclear export signal (NES)-dependent protein transport. It...
| Schlagworte: | Anti-CRM1, Anti-Exp1, Anti-XPO1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog, CRM1 Antibody |
| Anwendung: | WB, IHC (paraffin), IHC (frozen) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Anti-CRM1 (IHC)
Artikelnummer: IHC-00139
Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this...
| Schlagworte: | Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
D,L-1'-Acetoxychavicol Acetate
Artikelnummer: Cay19649-1
D,L-1'-Acetoxychavicol acetate is a natural compound first isolated from the rhizomes of ginger-like plants. It has a wide array of cellular effects that may be largely explained by its ability to inhibit exportin 1 and prevent the export of proteins from the nucleus. In this way, D,L-1'-acetoxychavicol acetate...
| Schlagworte: | 1'-Acetoxychavicol Acetate, ACA, Galangal Acetate, (alphaS)-4-(acetyloxy)-alpha-ethenyl-benzenemethanol, acetate |
| Anwendung: | Exportin 1 inhibitor |
| CAS | 53890-21-4 |
| MW: | 234.3 D |
ab 50,00 €
KPT-185
Artikelnummer: Cay26074-10
KPT-185 is an inhibitor of Exportin 1 (XPO1/CRM1) with anticancer activity. It reduces proliferation in a panel of patient-derived acute myeloid leukemia cells (IC50s = 100-500 nM). KPT-185 induces cell cycle arrest in the G1 phase and apoptosis in MOLT-4 T cell acute lymphoblastic leukemia cells and in a panel of...
| Schlagworte: | 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2Z-propenoic acid, 1-methylethyl ester |
| Anwendung: | XPO1/CRM1 nuclear export inhibitor |
| CAS | 1333151-73-7 |
| MW: | 355.3 D |
ab 84,00 €
Anti-Exportin 1 / XPO1 / CRM1, clone AEFD-24
Artikelnummer: NSJ-RQ4719
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN...
| Schlagworte: | Anti-CRM1, Anti-XPO1, Anti-Exp1, Anti-Exportin-1, Anti-Chromosome region maintenance 1 protein homolog, Exportin 1... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Leptomycin B, Free Acid (Elactocin, Mantuamycin, PD...
Artikelnummer: LC-L-6100_1mg
Solubility: Soluble in methanol or ethanol. More than 1,000 labs worldwide have purchased Leptomycin B from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels). Leptomycin B (LepB) is a potent, specific inhibitor of nuclear export signal (NES)-dependent...
| Schlagworte: | ATS 1287B, CI-940, CL-1957A, LMB, PD-114720, Elactocin, Mantuamycin, NSC 364372,... |
| Anwendung: | Potent, specific NES-dependen nuclear export inhibitor |
| CAS | 87081-35-4 |
| MW: | 540.73 D |
915,00 €