Anti-CLEC9A

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells.Flow cytometric, Western blot, and deglycosylation analyses showed surface expression of a glycosylated CLEC9A dimer of 40 and 45 kD under reducing conditions. The deglycosylated dimer was approximately 30 and 35 kD. RT-PCR detected CLEC9A expression in most human tissues examined, with highest levels in brain, thymus, and spleen. Protein function: Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. [The UniProt Consortium]