Anti-CD95 (human), Unconjugated Clone B-G27 [Mouse]

Specificity: Recognises the Fas, APO1 antigen, a 45 kDa protein, Format: Phosphate-buffered saline with 1 % BSA and 0.1 % sodium azide, Working Dilution: Use 10 µl to label 106 cells or 100 µl of whole blood, Storage: Stable at +2-8°C for 12 months For longer storage, freeze aliquots, Application Notes: Suitable for Flow Cytometry, IHC on frozen sections Protein function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [The UniProt Consortium]