Anti-CD45RA (human), Unconjugated Clone B-C15 [Mouse]

Specificity: Recognises the restricted Leucocyte Common Antigen (LCA) with different isoforms of 205/220 kDa, Format: Phosphate-buffered saline with 1 % BSA and 0.09 % sodium azide, Working Dilution: Use 10 µl to label 106 cells or 100 µl of whole blood, Storage: Stable at +2-8°C for 12 months. For longer storage freeze aliquots, Application Notes: Suitable for Flow Cytometry, IHC Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. [The UniProt Consortium]