Anti-CD41a (human), Unconjugated Clone HIP8 [Mouse]

Specificity: Reacts with CD41a antigen. CD41 (GPIIb) is a transmembrane glycoprotein (integrin family) composed of two chains GPIIbalpha and GPIIbbeta, Format: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4, Working Dilution: We recommend that each laboratory determine an optimum working titre for use in its particular application, Storage: Store at +2-8°C. For longer storage, freeze aliquots, Application Notes: Suitable for Flow Cytometry, IHC frozen Protein function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [The UniProt Consortium]