Anti-CD10, clone YN01896m

CD10, also known as common acute lymphoblastic leukemia antigen (CALLA), which is expressed in bone marrow hematopoietic stem cells (including neutrophils), follicular centroblasts, some mature B lymphocytes and parafollicular T lymphocytes. CD10 is also found in the upper layer of intestinal brush border cells, liver cholangiocarcinoma, glomeruli and renal tubular cells, alveolar cells, myoepithelial cells, breast, sweat gland, salivary gland, prostate cells and a small number of fibroblasts. CD10 is expressed in most acute lymphoblastic leukemia, follicular lymphoma and Burkitt's lymphoma. CD10 can be specifically used for the identification and classification of B-cell leukemia / lymphoma and other tumors, such as hepatocellular carcinoma and renal cell carcinoma. Protein function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:6349683, PubMed:6208535, PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu- enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:6349683, PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). [The UniProt Consortium]