Anti-c-Rel

Anti-c-Rel
Aktion:

Gratis T-Shirt zu jeder Rockland-Bestellung über 500 €. 

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
100-4166 100 µl - -

1 - 9 Werktage

471,00 €
 
Protein function: Proto-oncogene that may play a role in differentiation and lymphopoiesis.... mehr
Produktinformationen "Anti-c-Rel"
Protein function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. [The UniProt Consortium]
Schlagworte: Anti-REL, Anti-Proto-oncogene c-Rel
Hersteller-Nr: 100-4166

Eigenschaften

Anwendung: ELISA, WB, IP, GS
Antikörper-Typ: Polyclonal
Wirt: Rabbit
Reaktivität: Human
Immunogen: NFkappaB cRel peptide corresponding to the C-terminal region of human protein
Format: Serum

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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