Anti-BAT3

Anti-BAT3
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-038A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A302-038A-M 100 µl (10 blots) -

3 - 9 Werktage

290,00 €
A302-038A 100 µl (20 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Chaperone that plays a key role in various processes such as apoptosis,... mehr
Produktinformationen "Anti-BAT3"
Protein function: Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Moreover, it regulates the stability and the degradation of proteins by the proteasome. For instance, it is required for selective ubiquitin- mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno- proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. It is also involved in ubiquitin-mediated proteasomal degradation of proteins of the secretory pathway that are mislocalized to the cytosol. Binds the mislocalized proteins, preventing their aggregation in the cytosol, and promotes their ubiquitination. Participates in endoplasmic reticulum stress- induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2. [The UniProt Consortium]
Schlagworte: Anti-BAT3, Anti-BAG6, Anti-BAG-6, Anti-Protein G3, Anti-Protein Scythe, Anti-BCL2-associated athanogene 6, Anti-HLA-B-associated transcript 3, Anti-Large proline-rich protein BAG6, Anti-BAG family molecular chaperone regulator 6
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-038A-T

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Mouse, Rat)
Immunogen: synthetic peptide. The epitope recognized by A302-038A-T maps to a region between residue 200 and 250 of human HLA-B associated transcript 3 using the numbering given in entry NP_004630.3 (GeneID 7917).
Format: Antigen Affinity Purified

Datenbank Information

UniProt ID : P46379 | Suche mit UniProt ID
Gene ID GeneID 7917 | Suche mit Gene ID

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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