Anti-ASF

Anti-ASF
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A302-052A 100 µl (100 µg) -

3 - 9 Werktage

430,00 €
 
Protein function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and... mehr
Produktinformationen "Anti-ASF"
Protein function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. [The UniProt Consortium]
Schlagworte: Anti-ASF, Anti-ASF-1, Anti-SRSF1, Anti-Alternative-splicing factor 1, Anti-Serine/arginine-rich splicing factor 1, Anti-Splicing factor, arginine/serine-rich 1, Anti-pre-mRNA-splicing factor SF2, P33 subunit
Hersteller: Bethyl Laboratories
Hersteller-Nr: A302-052A

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Mouse, X. Tropicalis, Chicken, Bovine, Pig, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-052A maps to a region between residue 1 and 50 of human alternative splicing factor (splicing factor, arginine/serine-rich 1) using the numbering given in entry NP_008855.1 (GeneID 6426).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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