Anti-APPBP1

Anti-APPBP1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R31752 100 µg - -

3 - 10 Werktage*

755,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Amyloid beta precursor protein binding... mehr
Produktinformationen "Anti-APPBP1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Amyloid beta precursor protein binding protein 1 (APPBP1) binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPBP1 is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. Protein function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. [The UniProt Consortium]
Schlagworte: Anti-NAE1, Anti-HPP1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1, Anti-NEDD8-activating enzyme E1 regulatory subunit, Anti-Amyloid beta precursor protein-binding protein 1, 59 kDa, APPBP1 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: R31752

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Human partial recombinant protein (AA 181-534) was used as the immunogen for this APPBP1 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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