Zu "K04532" wurden 32 Artikel gefunden!
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MLN-4924
Artikelnummer: LKT-M4454.1
MLN4924 acts as a Nedd8-activating enzyme inhibitor, blocking proteasomal cullin protein neddylation by Cullin-RING E3 ubiquitin ligases. As a result, these proteins accumulate, inducing cell cycle arrest, senescence, autophagy, and/or apoptosis in cellular and animal models. This compound's inhibition of...
| Anwendung: | NEDD activating enzyme (NAE) inhibitor |
| CAS | 905579-51-3 |
| MW: | 443.16 D |
ab 224,00 €
Anti-APPBP1
Artikelnummer: NSJ-R31752
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Amyloid beta precursor protein binding protein 1 (APPBP1) binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded...
| Schlagworte: | Anti-NAE1, Anti-HPP1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-NAE1
Artikelnummer: E-AB-14592.120
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C...
| Schlagworte: | Anti-HPP1, Anti-NAE1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-NAE1 / APPBP1
Artikelnummer: ARG59154.100
Protein function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-NAE1, Anti-HPP1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
Anti-NAE1 / APPBP1
Artikelnummer: ARG59180.100
Protein function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-NAE1, Anti-HPP1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
616,00 €
Anti-NAE1
Artikelnummer: ATA-HPA041178.100
Protein function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-HPP1, Anti-NAE1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 246,00 €
Anti-NAE1
Artikelnummer: ATA-HPA042041.100
Protein function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-HPP1, Anti-NAE1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 246,00 €
Anti-NAE1
Artikelnummer: CSB-PA131191.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: NAE1. Antigen Species: Human
| Schlagworte: | Anti-HPP1, Anti-NAE1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-NAE1
Artikelnummer: CSB-PA195686.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: NAE1. Antigen Species: Human
| Schlagworte: | Anti-HPP1, Anti-NAE1, Anti-APPBP1, Anti-APP-BP1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Pevonedistat
Artikelnummer: TGM-T6332-100mg
Description: Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM) with therapeutic potential for myelodysplastic syndromes (MDS) and antitumor activity. Target: NEDD8, E1/E2/E3 Enzyme. Smiles: NS(=O)(=O)OC[C@@H]1CC(C[C@@H]1O)n1ccc2c(NC3CCc4ccccc34)ncnc12....
| Schlagworte: | MLN4924 |
| Anwendung: | Targets NEDD8-activating enzyme E1 regulatory subunit (NAE1, APPBP1) |
| CAS | 905579-51-3 |
| MW: | 443.52 D |
ab 46,00 €
NEU
![Anti-APPBP1 [R03-1A7] Monoclonal Antibody](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg "Anti-APPBP1 [R03-1A7] Monoclonal Antibody")
Anti-APPBP1 [R03-1A7] Monoclonal Antibody
Artikelnummer: G-AGMB00831.100
APPBP1 Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic...
| Schlagworte: | Anti-NAE1, Anti-Proto-oncogene protein 1, Anti-Amyloid protein-binding protein 1, Anti-NEDD8-activating enzyme E1... |
| Anwendung: | WB, FC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
ab 134,00 €
Anti-nae1
Artikelnummer: CSB-PA759672XA01DIL.100
Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1:...
| Schlagworte: | Anti-nae1, Anti-appbp1, Anti-APP-BP1, Anti-Amyloid protein-binding protein 1, Anti-NEDD8-activating enzyme E1 regulatory... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | Danio rerio (Zebrafish) (Brachydanio rerio) |
1.529,00 €