Anti-Adiponectin, clone ADPQ-1

Anti-Adiponectin, clone ADPQ-1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V7249SAF-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Adiponectin (commonly called ADIPO, or by... mehr
Produktinformationen "Anti-Adiponectin, clone ADPQ-1"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Adiponectin (commonly called ADIPO, or by the gene name ADIPOQ) is an adipocytokine, a hormone produced in adipose tissue. It is abundantly present in plasma and has insulin like effect on glucose levels in the blood. Plasma ADIPO levels are low in insulin resistant patients who are obese, have diabetes mellitus type 2 or HIV-lipodystrophy. In women, levels tend to be higher than in men, which may be due to androgens suppressing ADIPO levels. Furthermore, adiponectin and leptin are both indicated in regulating body weight through direct action on the hypothalamus, influencing appetite. Obese people have low ADIPO levels while levels in anorexia patients are high. Adiponectin acts as ligand for various receptors, two of which have been identified, one probably involved in carbohydrate assimilation, the other in tuning the rate of metabolism. Protein function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. [The UniProt Consortium]
Schlagworte: Anti-ACDC, Anti-apM-1, Anti-ADIPOQ, Anti-ACRP30, Anti-Adiponectin, Anti-Gelatin-binding protein, Anti-Adipocyte complement-related 30 kDa protein, Anti-30 kDa adipocyte complement-related protein, Anti-Adipose most abundant gene transcript 1 protein, Adip
Hersteller: NSJ Bioreagents
Hersteller-Nr: V7249SAF

Eigenschaften

Anwendung: ELISA, FC, IF, IHC
Antikörper-Typ: Monoclonal
Klon: ADPQ-1
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human. others not tested
Immunogen: A human partial recombinant protein was used as the immunogen for this Adiponectin antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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