Anti-Acrp30 (30kD Adipocyte Complement-related Protein, Adipocyte Complement-related 30kD Protein, A

Anti-Acrp30 (30kD Adipocyte Complement-related Protein, Adipocyte Complement-related 30kD Protein, A
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A0725-02Q.20 20 µl - -

3 - 19 Werktage*

395,00 €
A0725-02Q.100 100 µl - -

3 - 19 Werktage*

696,00 €
 
Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in... mehr
Produktinformationen "Anti-Acrp30 (30kD Adipocyte Complement-related Protein, Adipocyte Complement-related 30kD Protein, A"
Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in brown and white adipocytes (1). It is secreted into the blood and exists in three major forms: a low molecular weight trimer, a medium molecular weight hexamer and a high molecular weight multimer (1). Adiponectin levels are decreased in obese and insulin-resistant mice and humans (2), suggesting that this adipokine is critical to maintain insulin sensitivity. Adiponectin stimulates the phosphorylation of AMPKalpha at Thr172 and activates AMPK in skeletal muscle (3). It also stimulates glucose uptake in myocytes (3). The block of AMPK activation by a dominant-negative AMPKalpha2 isoform inhibits the effect of adiponectin on glucose uptake, indicating that adiponectin stimulates glucose uptake and increases insulin sensitivity through its action on AMPK (3). Adiponectin mutants that are not able to form oligomers larger than trimers have no effect on the AMPK pathway (4). Mutations that render adiponectin unable to form high molecular weight multimers are associated with human diabetes (4), indicating the importance of multimerization for adiponectin activity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted primary antibody in 5% BSA, 1X TBS, 0.1% Tween 20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: Anti-ACRP30, Anti-Gelatin-binding protein, Anti-Adipocyte complement-related 30 kDa protein, Anti-30 kDa adipocyte complement-related protein, Anti-Adipose most abundant gene transcript 1 protein
Hersteller: United States Biological
Hersteller-Nr: A0725-02Q

Eigenschaften

Anwendung: WB
Antikörper-Typ: Monoclonal
Klon: 10g127(C45B10)
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Synthetic peptide corresponding to human Acrp30.
Format: Supernatant

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-Acrp30 (30kD Adipocyte Complement-related Protein, Adipocyte Complement-related 30kD Protein, A"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen