Anti-ADAM17

Anti-ADAM17
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F44300-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F44300-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. ADAM17 is a member of the ADAM (a disintegrin and... mehr
Produktinformationen "Anti-ADAM17"
In 1X PBS, pH 7.4, with 0.09% sodium azide. ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme, binds mitotic arrest deficient 2 protein, and also plays a prominent role in the activation of the Notch signaling pathway. Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. [The UniProt Consortium]
Schlagworte: Anti-CSVP, Anti-ADAM17, Anti-CD156b, Anti-ADAM 17, EC=3.4.24.86, Anti-TNF-alpha convertase, Anti-Snake venom-like protease, Anti-TNF-alpha-converting enzyme, Anti-Disintegrin and metalloproteinase domain-containing protein 17, ADAM17 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F44300

Eigenschaften

Anwendung: WB, FC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 195-224 from the human protein was used as the immunogen for this ADAM17 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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