Anti-ACE2, ID (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting

Anti-ACE2, ID (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A2295-02D3.200 200 µl - -

3 - 19 Werktage*

728,00 €
 
ACE2 cDNA encodes a deduced 805aa protein containing a potential 17aa N-terminal signal peptide... mehr
Produktinformationen "Anti-ACE2, ID (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting"
ACE2 cDNA encodes a deduced 805aa protein containing a potential 17aa N-terminal signal peptide and a putative 22aa C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9aa. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus. Applications: Suitable for use in ELISA, Western Blot, Flow Cytometry, and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:50-1:200, ELISA: 1:1,000, Immunohistochemistry: 1:50-1:100 , Flow Cytometry: 1:10-1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: EC=3.4.17.23, Anti-ACE-related carboxypeptidase, Anti-Angiotensin-converting enzyme 2, Anti-Angiotensin-converting enzyme homolog, Anti-Processed angiotensin-converting enzyme 2
Hersteller: United States Biological
Hersteller-Nr: A2295-02D3

Eigenschaften

Anwendung: ELISA, FC, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Synthetic peptide selected from the center region of human ACE2 (KLH).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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