Recombinant Human ErbB3 Fragment

ErbB3 is one of four alphaembers of the epidermal growth factor (EGF) receptor family with no intrinsic kinase activity. Therefore, its signal transduction upon EGF ligand binding is carried by the heterodimerization of ErbB3 with a different EGF receptor kinase. ErbB3 is linked to cancer etiology and progression. Its expression can be found in keratinocytes, melanocytes, skeletal muscle cell, embryonic myoblasts and Schwann cells.