Mouse SHH, recombinant (C-6His)

Recombinant Mouse Sonic Hedgehog is produced by our Mammalian expression system and the target gene encoding Cys25­Gly198 is expressed with a 6His tag at the C-terminus. Protein function: [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (PubMed:8824192, PubMed:7891723). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (PubMed:8824192). Both activities occur in the reticulum endoplasmic (PubMed:21357747). Once cleaved, ShhC is degraded in the endoplasmic reticulum (PubMed:21357747). [The UniProt Consortium]