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Sonic HedgeHog, human recombinant (rHuSHH)
Sonic HedgeHog, human recombinant (rHuSHH)

Artikelnummer: 97290.25

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of...
Schlagworte: SHH, HHG-1, HHG1, Sonic hedgehog protein, TPT, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5
Anwendung: Cell culture
Reaktivität: Human
MW: 19683 D
ab 70,00 €
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Sonic Hedgehog/SHH (C-6His) (recombinant human)
Sonic Hedgehog/SHH (C-6His) (recombinant human)

Artikelnummer: E-PKSH033935.10

Protein Construction: Recombinant Human Sonic Hedgehog is produced by our Mammalian expression system and the target gene encoding Cys24-Gly197 is expressed with a 6His tag at the C-terminus. Sequence: Cys24-Gly197. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular...
Schlagworte: , Recombinant Human Sonic Hedgehog/SHH (C-6His)
Reaktivität: Human
MW: 20.4 kD
ab 144,00 €
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Sonic Hedgehog/SHH (C-6His) (recombinant mouse)
Sonic Hedgehog/SHH (C-6His) (recombinant mouse)

Artikelnummer: E-PKSM041416.10

Protein Construction: Recombinant Mouse Sonic Hedgehog is produced by our Mammalian expression system and the target gene encoding Cys25­Gly198 is expressed with a 6His tag at the C-terminus. Sequence: Cys25­-Gly198. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular...
Schlagworte: Hhg1, Recombinant Mouse Sonic Hedgehog/SHH (C-6His)
Reaktivität: Mouse
MW: 20.4 kD
ab 124,00 €
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Sonic Hedgehog, mouse recombinant (rmSHH)
Sonic Hedgehog, mouse recombinant (rmSHH)

Artikelnummer: 08546.5

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of...
Schlagworte: SHH, HHG-1, HHG1, Sonic hedgehog protein
Anwendung: Cell culture
Reaktivität: Mouse
MW: 19800.00 D
ab 70,00 €
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Celecoxib
Celecoxib

Artikelnummer: Cay10008672-250

Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 µM for COX-1 and COX-2, respectively). In vivo, celecoxib (0.3 ml of a 0.4% solution) administered intra-articularly reduces production of IL-1beta, TNF-alpha, and MMP-3 as well as articular cartilage damage in a rabbit model of osteoarthritis. It...
Schlagworte: SC-58635, YM-177, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Anwendung: COX-2 inhibitor
CAS 169590-42-5
MW: 381.4 D
ab 44,00 €
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Mouse Sonic Hedgehog (Shh), His-tag
Mouse Sonic Hedgehog (Shh), His-tag

Artikelnummer: BPS-91012

Mouse sonic hedgehog (mShh), also known as HHG-1. GenBank Accession No. NM_009170, a.a. 25-198 with a C-terminal His-tag, expressed in an E. coli cell expression system, MW = 20.5 kDa.
Schlagworte: Shh, Hhg1
Anwendung: Binding assays, Small molecule screening, Immunogen
Reaktivität: Mouse
MW: 20.5 kD
260,00 €
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Zerumbone
Zerumbone

Artikelnummer: Cay15400-5

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet. It potently inhibits the activation of Epstein-Barr virus by phorbol esters (IC50 = 140 nM). Zerumbone inhibits Sonic hedgehog signaling and induces apoptosis in cancer cell lines. It has also been shown to...
Schlagworte: (2E,6E)-2,6,9,9-tetramethyl-2,6,10E-cycloundecatrien-1-one
Anwendung: Sonic hedgehog signaling inhibitor, Apoptosis inducer
CAS 471-05-6
MW: 218.3 D
ab 38,00 €
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Robotnikinin
Robotnikinin

Artikelnummer: Cay13204-1

Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development. Shh binds to its receptor, Patched (Ptch1), resulting in the de-repression of Smoothened. This leads to the activation of Gli2, which regulates the transcription of...
Schlagworte: N-[(4-chlorophenyl)methyl]-5,12-dioxo-2R-phenyl-1-oxa-4-azacyclododec-8E-ene-6S-acetamide
Anwendung: Shh inhibitor
CAS 1132653-79-2
MW: 455 D
349,00 €
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Sonic Hedgehog
Sonic Hedgehog

Artikelnummer: 009-001-W24-0005

Sonic Hedgehog purity was determined to be greater than 97% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE. Protein function: Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral...
Schlagworte: SHH
Anwendung: Cell culture
Reaktivität: Human
140,00 €
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HhAntag
HhAntag

Artikelnummer: Cay28296-1

HhAntag is an inhibitor of the Sonic Hedgehog (Shh) pathway (EC50 = 0.4 µM for Shh signaling in a reporter assay). It inhibits proliferation of GNP cells when used at concentrations ranging from 0.1 nM to 25 µM. In vivo, HhAntag (20 or 100 mg/kg) suppresses Gli1 mRNA levels, a target of Shh signaling, and increases...
Schlagworte: N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxy-benzamide
Anwendung: Sonic Hedgehog (Shh) pathway inhibitor
CAS 496794-70-8
MW: 450.9 D
ab 32,00 €
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Anti-SHH
Anti-SHH

Artikelnummer: G-CAB7726.100

Anwendung: IHC, WB
Reaktivität: Human, Rat
314,00 €
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Human SHH (Hedgehog Homolog, Sonic) ELISA Kit
Human SHH (Hedgehog Homolog, Sonic) ELISA Kit

Artikelnummer: G-HUES02054.96

ELISA Type: Sandwich. Sensitivity: 46.875pg/mL. Range: 78.125--5000pg/mL. Protein function: [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into...
Anwendung: Sandwich ELISA
Reaktivität: Human
566,00 €
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