CXCL12, mouse recombinant

CXCL12, mouse recombinant
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ICT-6508 5 µg -

1 - 10 Werktage

271,00 €
The C-X-C motif chemokine CXCL12 binds to one single chemokine receptor, CXCR4, to mediate... mehr
Produktinformationen "CXCL12, mouse recombinant"
The C-X-C motif chemokine CXCL12 binds to one single chemokine receptor, CXCR4, to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 and its receptor CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis. Mouse CXCL12 Recombinant Protein is purified CXCL12 produced in yeast. Protein function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. [The UniProt Consortium]
Schlagworte: PBSF, TLSF, Sdf1, SDF-1, TPAR1, Cxcl12, C-X-C motif chemokine 12, Stromal cell-derived factor 1, Pre-B cell growth-stimulating factor, Thymic lymphoma cell-stimulating factor, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1
Hersteller: ImmunoChemistry Technologies
Hersteller-Nr: 6508


Anwendung: Cell culture, ELISA Standard, WB control
Konjugat: No
Exprimiert in: Yeast
Ursprungsart: Mouse
MW: 11.6 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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