Stromal Cell-Derived Factor-1 alpha (CXCL12)

Stromal Cell-Derived Factor-1 alpha (CXCL12)
Stromal Cell-Derived Factor-1 alpha (CXCL12)
   
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
010-001-W22-0100 100 µg - -

1 - 9 Werktage

714,00 €
 
Stromal Cell-Derived Factor-1 alpha (CXCL12) purity was determined to be greater than 98% as... mehr
Produktinformationen "Stromal Cell-Derived Factor-1 alpha (CXCL12)"
Stromal Cell-Derived Factor-1 alpha (CXCL12) purity was determined to be greater than 98% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE. Protein function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. [The UniProt Consortium]
Schlagworte: Sdf1, PBSF, TLSF, TPAR1, SDF-1, Cxcl12, C-X-C motif chemokine 12, Stromal cell-derived factor 1, Pre-B cell growth-stimulating factor, Thymic lymphoma cell-stimulating factor, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 010-001-W22-0100

Eigenschaften

Anwendung: Cell culture
Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Mouse

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +20°C (International: +20°C)
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Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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