USP2 active domain (human recombinant)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay22784-100 100 µg -

1 - 10 Werktage

344,00 €
Ubiquitin-specific protease 2 (USP2), also known as ubiquitin carboxyl-terminal hydrolase 2, is a... mehr
Produktinformationen "USP2 active domain (human recombinant)"
Ubiquitin-specific protease 2 (USP2), also known as ubiquitin carboxyl-terminal hydrolase 2, is a cysteine protease involved in intracellular protein degradation by deubiquitinating degraded protein, including Mdm2, Mdm4, and CCND1. In both normal and cancer cells, it regulates G1/S cell-cycle transition. It may regulate p53-dependent pathways by deubiquitinating Mdm2, indirectly promoting p53 degradation and limiting its activity.. Regulated by androgen, USP2 is over-expressed in prostate cancer and stabilizes fatty acid synthase (FASN), which is associated with the malignancy of some aggressive prostate cancers. Some of these oncogenic properties may be linked to its deubiquitinating activity. One hypothesis is that USP2 may stabilize short-lived proteins that may act to induce apoptosis. USP2 has also been shown to regulate the intrinsic circadian rhythm and its capacity to respond to external cues, in a non-degradative manner by acting on the core clock component PER1. This protein is a truncation containing the active catalytic domain (residues 259-605) of USP2 and a C-terminal His-tag.
Schlagworte: Ubiquitin C-terminal Hydrolase 2, Ubiquitin-specific Protease 2
Hersteller: Cayman Chemical
Hersteller-Nr: 22784-100


Anwendung: ELISA, Electrophoresis, HTS, MS, WB
Konjugat: No
Reinheit: >95% estimated by SDS-PAGE
Format: Solution

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -80°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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