SIRT6 (human, recombinant)

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-7. SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-kappaB signaling. Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature ageing disorder, and have a shortened life span. Since SIRT6 binds and attenuates NF-kappaB signaling, it is proposed that activators of SIRT6 may be effective anti-cancer and anti-inflammatory drugs and may increase longevity.Synonyms: NAD-dependent Deacetylase 6, Silent Information Regulator 6, SIR2L6, SIR2-like Protein 6, Sirtuin 6. Purity: >80% estimated by SDS-PAGE. Source: active recombinant N-terminal His-tagged enzyme expressed in E. coli. Amino Acids: 1-355. MW: 43.7 kDa. Formulation: (Request formulation change), 25 mM Tris-HCl, pH 8.0, with 100mM NaCl, 20% glycerol. UniProt Accession #: Q8N6T7.