Z-LEVD-FMK

Description: Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor with potential anticancer activity, capable of eliminating LPS-induced GCLC protein degradation and inducing apoptosis in cancer cells. Target: Caspase, Apoptosis. Smiles: [C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)(C(N[C@H](C(N[C@@H](CC(OC)=O)C(CF)=O)=O)C(C)C)=O)CCC(OC)=O. References: Feng WQ, et al. IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8 + T-cell tumour infiltration. J Transl Med. 2023 May 21,21(1):335.