Z-IETD-FMK

A peptide inhibitor of caspase-8, inhibits TNF-alpha-induced apoptosis in isolated human neutrophils at 3 or 10 µM, decreases HRV replication and HRV-induced apoptosis in HeLa cells at 100 µM, reduces tumor growth and increases tumor macrophage and T cell infiltration in a mouse model of NMU-induced lung cancer when intrathecally administered at 0.5 µg/animal