WE-NP Peptide Pool

Pool of 137 peptides derived from a peptide scan (15mers with 11 aa overlap) through Nucleoprotein (Uni-Prot ID A0A059U6M5_9VIRU) of Lymphocytic choriomeningitis mammarenavirus. One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and therby participates in the suppression of interferon induction. [The UniProt Consortium]