VZV (IE63) Peptide Pool

Pool of 67 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through Transcriptional transactivator IE63 (UniProt ID: Q77NN7-1) of Varicella-zoster virus (strain Oka vaccine) for T cell assays One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Immediate early (EI) protein that functions as a transcriptional regulator of cellular and viral mRNAs mainly by interacting with several general transcription factors thereby disorganizing the preinitiation complex at certain promoters. May additionally help to regulate levels of histones in virus-infected cells by interacting with host ASF1. By inhibiting host transcriptional program, IE63 plays a major role in the ability of VZV to overcome the innate immune response to the virus. [The UniProt Consortium]