Verucopeptin

Description: Verucopeptin is a pyranized cyclic peptide and an inhibitor of hypoxia-inducible factor 1 (HIF-1). It is an antibiotic effective against B16 melanoma, with anticancer activity, lowering the expression of HIF-1 target genes and HIF-1alpha protein levels. It can be used in cancer research. Target: Endogenous Metabolite, HIF, HIF/HIF Prolyl-Hydroxylase, Proton pump. Smiles: N(C([C@@](C)(O)C1(O)O[C@H](\C(=C\[C@H](C[C@H](C[C@@H](CC)C)C)C)\C)[C@@H](OC)CC1)=O)[C@H]2[C@H](C(C)C)OC(=O)CN(C)C(=O)CNC(=O)CN(C)C(=O)CN(O)C(=O)[C@@]3(N(C2=O)NCCC3)[H]